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Special cases: In patients with neurological symptoms, the frequency may be initially more frequent and maintained at shorter intervals for a longer period of time

These include medications containing the active pharmaceutical ingredient phenprocoumon and Warfarin

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Foundational studies published prior to 2013, such as those focusing on SCFAs and the brain-gut axis, will also be considered